Bibliographic Details
| Title: |
PM2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study |
| Authors: |
Tiantian Li, Jianlong Fang, Song Tang, Hang Du, Liang Zhao, Yanwen Wang, Fuchang Deng, Yuanyuan Liu, Yanjun Du, Liangliang Cui, Wanying Shi, Yan Wang, Jiaonan Wang, Yingjian Zhang, Xiaoyan Dong, Ying Gao, Yu Shen, Li Dong, Huichan Zhou, Qinghua Sun, Haoran Dong, Xiumiao Peng, Yi Zhang, Meng Cao, Hong Zhi, Jingyang Zhou, Xiaoming Shi |
| Source: |
The Innovation, Vol 3, Iss 2, Pp 100213- (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science (General) |
| Subject Terms: |
PM2.5, gut-brain axis, multi-omics, gut microbiota, tryptophan metabolism, Science (General), Q1-390 |
| More Details: |
Summary: Recent studies have shown that PM2.5 may activate the hypothalamus-pituitary-adrenal (HPA) axis by inducing hormonal changes, potentially explaining the increase in neurological and cardiovascular risks. In addition, an association between PM2.5 and gut microbiota and metabolites was established. The above evidence represents crucial parts of the gut-brain axis (GBA). In view of this evidence, we proposed a hypothesis that PM2.5 exposure may affect the HPA axis through the gastrointestinal tract microbiota pathway (GBA mechanism), leading to an increased risk of neurological and cardiovascular diseases. We conducted a real-world prospective repeated panel study in Jinan, China. At each visit, we measured real-time personal PM2.5 and collected fecal and blood samples. A linear mixed-effects model was used to analyze the association between PM2.5 and serum biomarkers, gut microbiota, and metabolites. We found that PM2.5 was associated with increased serum levels of hormones, especially the adrenocorticotropic hormone (ACTH) and cortisol, which are reliable hormones of the HPA axis. Gut microbiota and tryptophan metabolites and inflammation, which are important components of the GBA, were significantly associated with PM2.5. We also found links between PM2.5 and changes in the nervous and cardiovascular outcomes, e.g., increases of 19.77% (95% CI: −36.44, 125.69) in anxiety, 1.19% (95% CI: 0.65, 1.74) in fasting blood glucose (FBG), 2.09% (95% CI: 1.48, 2.70) in total cholesterol (TCHOL), and 0.93% (95% CI: 0.14, 1.72) in triglycerides (TG), were associated with 10 μg/m3 increase in PM2.5 at the lag 0–72 h, which represent the main effects of GBA. This study indicated the link between PM2.5 and the microbiota GBA for the first time, providing evidence of the potential mechanism for PM2.5 with neurological and cardiovascular system dysfunction. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2666-6758 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666675822000091; https://doaj.org/toc/2666-6758 |
| DOI: |
10.1016/j.xinn.2022.100213 |
| Access URL: |
https://doaj.org/article/81dcda9bab45477fbd64759f11c56e24 |
| Accession Number: |
edsdoj.81dcda9bab45477fbd64759f11c56e24 |
| Database: |
Directory of Open Access Journals |
