An epigenome-wide association study of sex-specific chronological ageing

Bibliographic Details
Title:	An epigenome-wide association study of sex-specific chronological ageing
Authors:	Daniel L. McCartney, Futao Zhang, Robert F. Hillary, Qian Zhang, Anna J. Stevenson, Rosie M. Walker, Mairead L. Bermingham, Thibaud Boutin, Stewart W. Morris, Archie Campbell, Alison D. Murray, Heather C. Whalley, David J. Porteous, Caroline Hayward, Kathryn L. Evans, Tamir Chandra, Ian J. Deary, Andrew M. McIntosh, Jian Yang, Peter M. Visscher, Allan F. McRae, Riccardo E. Marioni
Source:	Genome Medicine, Vol 12, Iss 1, Pp 1-11 (2019)
Publisher Information:	BMC, 2019.
Publication Year:	2019
Collection:	LCC:Medicine LCC:Genetics
Subject Terms:	DNA methylation, Ageing, Sexual dimorphism, X chromosome, Generation Scotland, Medicine, Genetics, QH426-470
More Details:	Abstract Background Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown to be associated with both age and sex. Here, we investigate age-by-sex differences in blood-based DNA methylation in an unrelated cohort of 2586 individuals between the ages of 18 and 87 years, with replication in a further 4450 individuals between the ages of 18 and 93 years. Methods Linear regression models were applied, with stringent genome-wide significance thresholds (p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1756-994X
Relation:	https://doaj.org/toc/1756-994X
DOI:	10.1186/s13073-019-0693-z
Access URL:	https://doaj.org/article/8184cb0748bd44328eeb2be72f9dbcf1
Accession Number:	edsdoj.8184cb0748bd44328eeb2be72f9dbcf1
Database:	Directory of Open Access Journals
Full text is not displayed to guests.	Login for full access.

More Details
ISSN:	1756994X
DOI:	10.1186/s13073-019-0693-z
Published in:	Genome Medicine
Language:	English