Bibliographic Details
| Title: |
Telbivudine can safely reduce mother-to-child transmission in chronic hepatitis B women after 12 weeks of gestation |
| Authors: |
Li-fen Han, Jian-ming Zheng, Li-qing Zheng, Hai-bing Gao, Li-xia Chen, Qing-ling Xu, Yi-hong Chai, Xin Zhang, Chen Pan, Lv-feng Yao |
| Source: |
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019) |
| Publisher Information: |
BMC, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Telbivudine, Mother-to-child transmission, Chronic hepatitis B, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Abstract Background To evaluate the efficacy and safety of telbivudine in chronic hepatitis B women during the second and third trimesters of pregnancy. Methods The week 12–34 of pregnant women were screened in this prospective non-intervention study, with HBV DNA > 106 IU/mL and alanine aminotransferase > 50 IU/L. The patients were received telbivudine treatment as a treatment group or without antiviral treatment as a control group. All infants were received recombinant hepatitis B vaccine 10 μg within 12 h of birth, at week 4 and week 24, immunoglobulin G within 12 h of birth and were detected HBV markers at the range from 7 to 12 months after delivery. Results A total of 241 patients were finally enrolled, 139 patients in telbivudine group and 102 patients in control group. HBsAg negative rate of infants was 99.3% (135/136) in telbivudine group and was 91.9% (91/99) in control group after 7 months (P = 0.005), respectively. The incidence of undetectable HBV DNA levels (47.5%) was significantly lower in telbivudine-treated mothers than that in the controls (0%), and 75.5% patients alanine aminotransferase returned to normal in telbivudine group, and 51% in control group at delivery (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2334 |
| Relation: |
http://link.springer.com/article/10.1186/s12879-019-4250-6; https://doaj.org/toc/1471-2334 |
| DOI: |
10.1186/s12879-019-4250-6 |
| Access URL: |
https://doaj.org/article/8157ef5205604674b9982996c90c27fb |
| Accession Number: |
edsdoj.8157ef5205604674b9982996c90c27fb |
| Database: |
Directory of Open Access Journals |
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