Academic Journal
Comparison of the Proliferation and Differentiation Potential of Human Urine-, Placenta Decidua Basalis-, and Bone Marrow-Derived Stem Cells
| Title: | Comparison of the Proliferation and Differentiation Potential of Human Urine-, Placenta Decidua Basalis-, and Bone Marrow-Derived Stem Cells |
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| Authors: | Chengguang Wu, Long Chen, Yi-zhou Huang, Yongcan Huang, Ornella Parolini, Qing Zhong, Xiaobin Tian, Li Deng |
| Source: | Stem Cells International, Vol 2018 (2018) |
| Publisher Information: | Hindawi Limited, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Internal medicine |
| Subject Terms: | Internal medicine, RC31-1245 |
| More Details: | Human multipotent stem cell-based therapies have shown remarkable potential in regenerative medicine and tissue engineering applications due to their abilities of self-renewal and differentiation into multiple adult cell types under appropriate conditions. Presently, human multipotent stem cells can be isolated from different sources, but variation among their basic biology can result in suboptimal selection of seed cells in preclinical and clinical research. Thus, the goal of this study was to compare the biological characteristics of multipotent stem cells isolated from human bone marrow, placental decidua basalis, and urine, respectively. First, we found that urine-derived stem cells (USCs) displayed different morphologies compared with other stem cell types. USCs and placenta decidua basalis-derived mesenchymal stem cells (PDB-MSCs) had superior proliferation ability in contrast to bone marrow-derived mesenchymal stem cells (BMSCs); these cells grew to have the highest colony-forming unit (CFU) counts. In phenotypic analysis using flow cytometry, similarity among all stem cell marker expression was found, excluding CD29 and CD105. Regarding stem cell differentiation capability, USCs were observed to have better adipogenic and endothelial abilities as well as vascularization potential compared to BMSCs and PDB-MSCs. As for osteogenic and chondrogenic induction, BMSCs were superior to all three stem cell types. Future therapeutic indications and clinical applications of BMSCs, PDB-MSCs, and USCs should be based on their characteristics, such as growth kinetics and differentiation capabilities. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1687-966X 1687-9678 |
| Relation: | https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678 |
| DOI: | 10.1155/2018/7131532 |
| Access URL: | https://doaj.org/article/80f0a1288b08421b8b20f866e2b9a386 |
| Accession Number: | edsdoj.80f0a1288b08421b8b20f866e2b9a386 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1687966X 16879678 |
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| DOI: | 10.1155/2018/7131532 |
| Published in: | Stem Cells International |
| Language: | English |