Bibliographic Details
| Title: |
Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy. |
| Authors: |
Takashi Kasai, Takahiko Tokuda, Takuma Ohmichi, Ryotaro Ishii, Harutsugu Tatebe, Masanori Nakagawa, Toshiki Mizuno |
| Source: |
PLoS ONE, Vol 11, Iss 1, p e0147574 (2016) |
| Publisher Information: |
Public Library of Science (PLoS), 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
The COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this gene have recently been identified in families with multiple system atrophy (MSA). Moreover, specific heterozygous variants in the COQ2 gene have also been reported to confer susceptibility to sporadic MSA in Japanese cohorts. These findings have suggested the potential usefulness of CoQ10 as a blood-based biomarker for diagnosing MSA. This study measured serum levels of CoQ10 in 18 patients with MSA, 20 patients with Parkinson's disease and 18 control participants. Although differences in total CoQ10 (i.e., total levels of serum CoQ10 and its reduced form) among the three groups were not significant, total CoQ10 level corrected by serum cholesterol was significantly lower in the MSA group than in the Control group. Our findings suggest that serum CoQ10 can be used as a biomarker in the diagnosis of MSA and to provide supportive evidence for the hypothesis that decreased levels of CoQ10 in brain tissue lead to an increased risk of MSA. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC4727813?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0147574 |
| Access URL: |
https://doaj.org/article/80ee95b66052463a9b3bb77ba34f55d0 |
| Accession Number: |
edsdoj.80ee95b66052463a9b3bb77ba34f55d0 |
| Database: |
Directory of Open Access Journals |
