Bibliographic Details
| Title: |
Fusion pores with low conductance are cation selective |
| Authors: |
Joannalyn B. Delacruz, Satyan Sharma, Shailendra Singh Rathore, Meng Huang, Joan S. Lenz, Manfred Lindau |
| Source: |
Cell Reports, Vol 36, Iss 8, Pp 109580- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
fusion pore, ion selectivity, exocytosis, transmitter release, vesicle fusion, SNARE complex, Biology (General), QH301-705.5 |
| More Details: |
Summary: Many neurotransmitters are organic ions that carry a net charge, and their release from secretory vesicles is therefore an electrodiffusion process. The selectivity of early exocytotic fusion pores is investigated by combining electrodiffusion theory, measurements of amperometric foot signals from chromaffin cells with anion substitution, and molecular dynamics simulation. The results reveal that very narrow fusion pores are cation selective, but more dilated fusion pores become anion permeable. The transition occurs around a fusion pore conductance of ∼300 pS. The cation selectivity of a narrow fusion pore accelerates the release of positively charged transmitters such as dopamine, noradrenaline, adrenaline, serotonin, and acetylcholine, while glutamate release may require a more dilated fusion pore. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124721010147; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2021.109580 |
| Access URL: |
https://doaj.org/article/c8095224b4684a79971f49a0a4a9d2fe |
| Accession Number: |
edsdoj.8095224b4684a79971f49a0a4a9d2fe |
| Database: |
Directory of Open Access Journals |
