Bibliographic Details
| Title: |
The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer: a randomized placebo-controlled double-blind clinical trial |
| Authors: |
Yasaman Khazaei, Ali Basi, Maria Luz Fernandez, Hossein Foudazi, Rafat Bagherzadeh, Farzad Shidfar |
| Source: |
BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-21 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Other systems of medicine |
| Subject Terms: |
Chemotherapy-induced side Effects, Breast Cancer, Synbiotcs, Other systems of medicine, RZ201-999 |
| More Details: |
Abstract Background The prevalence of breast cancer and its mortality rate are increasing rapidly among women worldwide. On other hand, the courses of chemotherapy as the main treatment for these patients are too much exhaustive and annoying. This study was designed to evaluate the use of synbiotics (probiotics + prebiotics) supplementation as a safe and inexpensive adjuvant treatment in reducing common chemotherapy side effects in women with breast cancer. Methods The current study was conducted on 67 women with definitive diagnosis of breast cancer who were hospitalized to receive one-day chemotherapy sessions, and met the inclusion criteria. The patients were randomly allocated to the intervention or control group to receive synbiotics or placebo, respectively. They received oral consumption of synbiotics supplements twice a day for 8 weeks. The primary outcome was the changes in severity or experience of chemotherapy complication, analyzed by intention to treat (ITT). The instruments included 7 validated questionnaires which were used to assess chemotherapy complications in the initiation, 4 weeks and 8 weeks after intervention. Dietary intake was measured by 24-h dietary recall at the beginning, week 4 and week 8. Data were analyzed by SPSS software version 24. P-value |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2662-7671 |
| Relation: |
https://doaj.org/toc/2662-7671 |
| DOI: |
10.1186/s12906-023-04165-8 |
| Access URL: |
https://doaj.org/article/808f96c81e3b4606b4e8df791eb19612 |
| Accession Number: |
edsdoj.808f96c81e3b4606b4e8df791eb19612 |
| Database: |
Directory of Open Access Journals |
