Bibliographic Details
| Title: |
A simplified non-coplanar volumetric modulated arc therapy for the whole brain radiotherapy with hippocampus avoidance |
| Authors: |
Juan Xue, Sunian Jin, Hongtao Zhang, Kun Zou, Junxiu Sheng, Jinhai Tang, Wanying Zhao, Ping Yang, Lufan Tang, Xiupeng Lv, Li Lv |
| Source: |
Frontiers in Oncology, Vol 13 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
hippocampal avoiding, whole brain radiation therapy, brain metastases, IMRT, VMAT, coplanar, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
PurposeTo evaluate the feasibility of using a simplified non-coplanar volumetric modulated arc therapy (NC-VMAT) and investigate its dosimetric advantages compared with intensity modulated radiation therapy (IMRT) and coplanar volumetric modulated arc therapy (C-VMAT) for hippocampal-avoidance whole brain radiation therapy (HA-WBRT).MethodsTen patients with brain metastase (BM) were included for HA-WBRT. Three treatment plans were generated for each case using IMRT, C-VMAT, and NC-VMAT, respectively.ResultsThe dosimetric results of the three techniques complied roughly with the RTOG 0933 criteria. After dose normalization, the V30Gy of whole brain planned target volume (WB-PTV) in all the plans was controlled at 95%. Homogeneity index (HI) of WB-PTV was significantly reduced in NC-VMAT (0.249 ± 0.017) over IMRT (0.265 ± 0.020, p=0.005) and C-VMAT (0.261 ± 0.014, p=0.020). In terms of conformity index (CI), NC-VMAT could provide a value of 0.821 ± 0.010, which was significantly superior to IMRT (0.788 ± 0.019, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2023.1143564/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2023.1143564 |
| Access URL: |
https://doaj.org/article/807f677562b0446c9646c7770c5c549b |
| Accession Number: |
edsdoj.807f677562b0446c9646c7770c5c549b |
| Database: |
Directory of Open Access Journals |
