Bibliographic Details
| Title: |
Comparison of dalbavancin with standard of care in the management of infective endocarditis: efficacy, safety, and cost analysis |
| Authors: |
Milagros Suárez, Antonio Pérez-Landeiro, Ana Sanjurjo, Olalla Lima, Adrián Sousa, Ana López, Lucía Martínez-Lamas, Xurxo Cabrera, Martín Rubianes, María Teresa Pérez-Rodríguez |
| Source: |
International Journal of Infectious Diseases, Vol 138, Iss , Pp 41-45 (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Infective endocarditis, Sequential therapy, Dalbavancin, Cost analysis, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Objectives: Due to its long half-life, dalbavancin offers benefits for long-duration treatments, especially osteoarticular and infective endocarditis (IE). We evaluated the efficacy and costs of IE treatment, comparing dalbavancin with standard of care (SOC). Methods: Retrospective multicenter cohort study of adult patients with Gram-positive cocci definite IE. Dalbavancin was used as a sequential therapy before discharge. Efficacy was a combined variable of clinical cure and absence of recurrence in 12-month follow-up. Length of hospital stay and the associated costs were analyzed in both groups of treatment. Results: Twenty-two patients received dalbavancin and 47 SOC. The efficacy was similar between the groups (dalbavancin 18 [72%] vs SOC 44 [94%], P = 0.198). Hospital stay was shorter in the dalbavancin group (dalbavancin 22 days [16-34] vs SOC 37 days [23-49], P = 0.001), especially in those with E. faecalis IE (dalbavancin 30 days [20-36] vs SOC 65 days [46-74], P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971223007646; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2023.11.003 |
| Access URL: |
https://doaj.org/article/7f8f0435666a42acbd809d517e741c37 |
| Accession Number: |
edsdoj.7f8f0435666a42acbd809d517e741c37 |
| Database: |
Directory of Open Access Journals |
