Academic Journal
Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials
| Title: | Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials |
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| Authors: | Biyun Zhang, Xiuhua Yao, Xingming Zhong, Yang Hu, Jianying Xu |
| Source: | Heliyon, Vol 9, Iss 3, Pp e14291- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Polycystic ovary syndrome, Vitamin D, Treatment, Care, Meta-analysis, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Background: Vitamin D level is closely associated with the development of polycystic ovary syndrome (PCOS). We aimed to systematically evaluate the effects of vitamin D supplementation on patients with PCOS, to provide reliable evidence to the clinical treatment of PCOS. Methods: We searched PubMed, Medline, EMbase, Cochrane Library, Web of Science, WanFang, China national knowledge infrastructure(CNKI) and Weipu databases for randomized controlled trials (RCTs) on vitamin D supplementation for the treatment of PCOS. Two reviewers independently screened literature, extracted data and evaluated the risk of bias of included RCTs. RevMan 5.3 software was used for meta-analysis. Results: 13 RCTs with 840 PCOS patients were included finally. Meta-analyses indicated that vitamin D supplementation increase the serum vitamin D level[mean difference(MD) = 17.81, 95% confidence interval(CI) (10.65, 24.97)] and endometrial thickness [MD = 1.78, 95%CI (0.49, 3.06), P = 0.007], reduce the serum hs-CRP [MD = −0.54, 95%CI (−1.00, −0.08)], parathyroid hormone[MD = −14.76, 95%CI (−28.32, −1.19)], total cholesterol[MD = −12.00, 95%CI (−18.36, −5.56)] and total testosterone level [MD = −0.17, 95%CI (−0.29, −0.05)] (all p 0.05). Egger's tests showed that there were no publication biases in every synthesized result (all P > 0.05). Conclusion: Vitamin D may be helpful to improve the endocrine and metabolism-related indexes in patients with PCOS. More high-quality studies with larger sample size are warranted to further evaluate the role of vitamin D supplementation in patients with PCOS. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023014986; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e14291 |
| Access URL: | https://doaj.org/article/7f0daf01e0aa47909ed51f4a2cc5c0fe |
| Accession Number: | edsdoj.7f0daf01e0aa47909ed51f4a2cc5c0fe |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e14291 |
| Published in: | Heliyon |
| Language: | English |