Bibliographic Details
| Title: |
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development |
| Authors: |
Yuanyuan Shi, Xiaoqing Hu, Jin Cheng, Xin Zhang, Fengyuan Zhao, Weili Shi, Bo Ren, Huilei Yu, Peng Yang, Zong Li, Qiang Liu, Zhenlong Liu, Xiaoning Duan, Xin Fu, Jiying Zhang, Jianquan Wang, Yingfang Ao |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-09839-x |
| Access URL: |
https://doaj.org/article/a7efca7978f544758c5cefbd8525834b |
| Accession Number: |
edsdoj.7efca7978f544758c5cefbd8525834b |
| Database: |
Directory of Open Access Journals |
