Bibliographic Details
| Title: |
Radiation-Induced Heart Disease: Pathologic Abnormalities and Putative Mechanisms |
| Authors: |
Neil K Taunk, Bruce G Haffty, John B. Kostis, Sharad eGoyal |
| Source: |
Frontiers in Oncology, Vol 5 (2015) |
| Publisher Information: |
Frontiers Media S.A., 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
breast cancer, radiation therapy, Heart disease, radiation side effects, cardiac effects, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Breast cancer is a common diagnosis in women. Breast radiation has become a critical in managing patients who receive breast conserving surgery, or have certain high-risk features after mastectomy. Most patients have an excellent prognosis, therefore understanding the late effects of radiation to the chest is important. Radiation induced heart disease (RIHD) comprises a spectrum of cardiac pathology including myocardial fibrosis and cardiomyopathy, coronary artery disease, valvular disease, pericardial disease, and arrhythmias. Tissue fibrosis is a common mediator in RIHD. Multiple pathways converge with both acute and chronic cellular, molecular, and genetic changes to result in fibrosis. In this article, we review the pathophysiology of cardiac disease related to radiation therapy to the chest. Our understanding of these mechanisms has improved substantially, but much work remains to further refine radiation delivery techniques and develop therapeutics to battle late effects of radiation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00039/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2015.00039 |
| Access URL: |
https://doaj.org/article/7e900dd7d70d476f969afca9c2f50edd |
| Accession Number: |
edsdoj.7e900dd7d70d476f969afca9c2f50edd |
| Database: |
Directory of Open Access Journals |
