Molecular Mapping of Urinary Complement Peptides in Kidney Diseases

Bibliographic Details
Title: Molecular Mapping of Urinary Complement Peptides in Kidney Diseases
Authors: Ralph Wendt, Justyna Siwy, Tianlin He, Agnieszka Latosinska, Thorsten Wiech, Peter F. Zipfel, Aggeliki Tserga, Antonia Vlahou, Harald Rupprecht, Lorenzo Catanese, Harald Mischak, Joachim Beige
Source: Proteomes, Vol 9, Iss 4, p 49 (2021)
Publisher Information: MDPI AG, 2021.
Publication Year: 2021
Collection: LCC:Microbiology
Subject Terms: complement, peptide, urine, biomarker, kidney disease, proteomics, Microbiology, QR1-502
More Details: Defective complement activation has been associated with various types of kidney disease. This led to the hypothesis that specific urine complement fragments may be associated with kidney disease etiologies, and disease progression may be reflected by changes in these complement fragments. We investigated the occurrence of complement fragments in urine, their association with kidney function and disease etiology in 16,027 subjects, using mass spectrometry based peptidomics data from the Human Urinary Proteome/Peptidome Database. Twenty-three different urinary peptides originating from complement proteins C3, C4 and factor B (CFB) could be identified. Most C3-derived peptides showed inverse association with estimated glomerular filtration rate (eGFR), while the majority of peptides derived from CFB demonstrated positive association with eGFR. Several peptides derived from the complement proteins C3, C4 and CFB were found significantly associated with specific kidney disease etiologies. These peptides may depict disease-specific complement activation and could serve as non-invasive biomarkers to support development of complement interventions through assessing complement activity for patients’ stratification and monitoring of drug impact. Further investigation of these complement peptides may provide additional insight into disease pathophysiology and could possibly guide therapeutic decisions, especially when targeting complement factors.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2227-7382
Relation: https://www.mdpi.com/2227-7382/9/4/49; https://doaj.org/toc/2227-7382
DOI: 10.3390/proteomes9040049
Access URL: https://doaj.org/article/7e8ebd244afd4f9091edf50c0554b3e4
Accession Number: edsdoj.7e8ebd244afd4f9091edf50c0554b3e4
Database: Directory of Open Access Journals
More Details
ISSN:22277382
DOI:10.3390/proteomes9040049
Published in:Proteomes
Language:English