Bibliographic Details
| Title: |
Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4 |
| Authors: |
Chenxi Cao, Yuanyuan Shi, Xin Zhang, Qi Li, Jiahao Zhang, Fengyuan Zhao, Qingyang Meng, Wenli Dai, Zhenlong Liu, Wenqiang Yan, Xiaoning Duan, Jiying Zhang, Xin Fu, Jin Cheng, Xiaoqing Hu, Yingfang Ao |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling, implicating the cholesterol-LRP3-SDC4 axis in osteoarthritic cartilage degeneration. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-34830-4 |
| Access URL: |
https://doaj.org/article/7d96e89042cf47c4b45043d759f7024c |
| Accession Number: |
edsdoj.7d96e89042cf47c4b45043d759f7024c |
| Database: |
Directory of Open Access Journals |
