Bibliographic Details
| Title: |
Mycobacterium tuberculosis cough aerosol culture status associates with host characteristics and inflammatory profiles |
| Authors: |
Videlis Nduba, Lilian N. Njagi, Wilfred Murithi, Zipporah Mwongera, Jodi Byers, Gisella Logioia, Glenna Peterson, R. Max Segnitz, Kevin Fennelly, Thomas R. Hawn, David J. Horne |
| Source: |
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024) |
| Publisher Information: |
Nature Portfolio, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Abstract Interrupting transmission events is critical to tuberculosis control. Cough-generated aerosol cultures predict tuberculosis transmission better than microbiological or clinical markers. We hypothesize that highly infectious individuals with pulmonary tuberculosis (positive for cough aerosol cultures) have elevated inflammatory markers and unique transcriptional profiles compared to less infectious individuals. We performed a prospective, longitudinal study using cough aerosol sampling system. We enrolled 142 participants with treatment-naïve pulmonary tuberculosis in Kenya and assessed the association of clinical, microbiologic, and immunologic characteristics with Mycobacterium tuberculosis aerosolization and transmission in 129 household members. Contacts of the forty-three aerosol culture-positive participants (30%) are more likely to have a positive interferon-gamma release assay (85% vs 53%, P = 0.006) and higher median IFNγ level (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-024-52122-x |
| Access URL: |
https://doaj.org/article/a7d82d23d6dc43fd97572f94b9dede54 |
| Accession Number: |
edsdoj.7d82d23d6dc43fd97572f94b9dede54 |
| Database: |
Directory of Open Access Journals |
