Academic Journal
Mechanisms of Gills Response to Cadmium Exposure in Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis): Oxidative Stress, Immune Response, and Energy Metabolism
| Title: | Mechanisms of Gills Response to Cadmium Exposure in Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis): Oxidative Stress, Immune Response, and Energy Metabolism |
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| Authors: | Xuanxuan Zhang, Wenquan Zhang, Linlin Zhao, Li Zheng, Bingshu Wang, Chengbing Song, Shenghao Liu |
| Source: | Animals, Vol 14, Iss 4, p 561 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Veterinary medicine LCC:Zoology |
| Subject Terms: | cadmium stress, transcriptomics, metabolomics, oxidative stress, energy metabolism disorder, immune response, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| More Details: | Cadmium (Cd) pollution has become a global issue due to industrial and agricultural developments. However, the molecular mechanism of Cd-induced detrimental effects and relevant signal transduction/metabolic networks are largely unknown in marine fishes. Here, greenfin horse-faced filefish (Thamnaconus septentrionalis) were exposed to 5.0 mg/L Cd up to 7 days. We applied both biochemical methods and multi-omics techniques to investigate how the gills respond to Cd exposure. Our findings revealed that Cd exposure caused the formation of reactive oxygen species (ROS), which in turn activated the MAPK and apoptotic pathways to alleviate oxidative stress and cell damage. Glycolysis, protein degradation, as well as fatty acid metabolism might assist to meet the requirements of nutrition and energy under Cd stress. We also found that long-term (7 days, “long-term” means compared to 12 and 48 h) Cd exposure caused the accumulation of succinate, which would in turn trigger an inflammatory response and start an immunological process. Moreover, ferroptosis might induce inflammation. Overall, Cd exposure caused oxidative stress, energy metabolism disturbance, and immune response in greenfin horse-faced filefish. Our conclusions can be used as references for safety risk assessment of Cd to marine economic fishes. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2076-2615 |
| Relation: | https://www.mdpi.com/2076-2615/14/4/561; https://doaj.org/toc/2076-2615 |
| DOI: | 10.3390/ani14040561 |
| Access URL: | https://doaj.org/article/7d7f2398825c4223bdbc2d1e5d836e78 |
| Accession Number: | edsdoj.7d7f2398825c4223bdbc2d1e5d836e78 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20762615 |
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| DOI: | 10.3390/ani14040561 |
| Published in: | Animals |
| Language: | English |