Bibliographic Details
| Title: |
Regulation of pyroptosis by NF-κB signaling |
| Authors: |
Ling Yang, Yan Zhang, Zhuodong Chai, Yuqi Zhou, Zhenyu Li, Yinan Wei |
| Source: |
Frontiers in Cell Death, Vol 3 (2025) |
| Publisher Information: |
Frontiers Media S.A., 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
pyroptosis, NF-κB, inflammasome, infection, inflammation, Biology (General), QH301-705.5 |
| More Details: |
Pyroptosis is a form of proinflammatory cell death characterized by inflammasome activation, pore formation, and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 upon cell rupture. Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor, plays a critical role in immune system regulation. Recent research highlights the multifaceted roles of NF-κB signaling in pyroptosis. Various immunologically relevant ligands and their receptors can activate the NF-κB pathway to promote pyroptosis, with Toll-like receptors (TLRs), IL-1 receptors (IL-1Rs), and TNF receptors (TNFRs) being the most prominent. NF-κB regulates the transcription of key components of inflammasomes involved in pyroptosis, particularly the NLRP3 inflammasome. Recent studies also indicate that NF-κB modulates the activation of NLRC4 and AIM2 inflammasomes through distinct pathways in diverse inflammatory conditions, such as acute lung injury and neuroinflammation. Additionally, the NF-κB pathway mediates the production of inflammatory cytokines, including IL-1β, IL-33, and TNF-α, which further regulate pyroptosis. This review examines recent advances in understanding the role of the NF-κB signaling pathway in regulating pyroptosis during infection and inflammation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2813-5563 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fceld.2024.1503799/full; https://doaj.org/toc/2813-5563 |
| DOI: |
10.3389/fceld.2024.1503799 |
| Access URL: |
https://doaj.org/article/e7d5becb4d0c4939a05235a5071ee01a |
| Accession Number: |
edsdoj.7d5becb4d0c4939a05235a5071ee01a |
| Database: |
Directory of Open Access Journals |
