| Title: |
Prognostic value of the neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis |
| Authors: |
Chengbing Wang, Qian Zhang, Mingwei Ji, Jing Mang, Zhongxin Xu |
| Source: |
BMC Neurology, Vol 21, Iss 1, Pp 1-9 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
Acute ischemic stroke, Neutrophil-to-lymphocyte ratio, Intravenous thrombolysis, Hemorrhagic transformation, Functional outcome, Meta-analysis, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Abstract Background The relationship between the neutrophil-to-lymphocyte ratio (NLR) and poor prognostics in acute ischemic stroke (AIS) patients who receive intravenous thrombolysis (IVT) remains controversial. The purpose of this systematic review and meta-analysis was to evaluate the association between the NLR and poor prognosis after IVT. Furthermore, we aimed to determine whether the NLR at admission or post-IVT plays a role in AIS patients who received IVT. Methods The PubMed, Embase, Web of Science and China National Knowledge Infrastructure databases were searched for relevant articles until October 7, 2020. Cohort and case-control studies were included if they were related to the NLR in AIS patients treated with IVT. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were pooled to estimate the relationship between NLR and poor prognosis after IVT. A random effects model was used to calculate the pooled data. Results Twelve studies, including 3641 patients, met the predefined inclusion criteria. Higher NLRs were associated with an increased risk of hemorrhagic transformation (HT) (OR = 1.33, 95 % CI = 1.14–1.56, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2377 |
| Relation: |
https://doaj.org/toc/1471-2377 |
| DOI: |
10.1186/s12883-021-02222-8 |
| Access URL: |
https://doaj.org/article/a7d47535b7f14bc0a0de8e5522fb1ec6 |
| Accession Number: |
edsdoj.7d47535b7f14bc0a0de8e5522fb1ec6 |
| Database: |
Directory of Open Access Journals |
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