| Title: |
GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise |
| Authors: |
Axel Labour, Marlène Lac, Lucas Frassin, Benjamin Lair, Enda Murphy, Claire Maslo, Laurent Monbrun, Marie-Lou Calmy, Marie Marquès, Nathalie Viguerie, Geneviève Tavernier, Pierre Gourdy, Donal O’Gorman, Emilie Montastier, Claire Laurens, Alexandra Montagner, Cedric Moro |
| Source: |
Cell Reports, Vol 43, Iss 8, Pp 114577- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
CP: Metabolism, Biology (General), QH301-705.5 |
| More Details: |
Summary: Growth and differentiation factor 15 (GDF15) has recently emerged as a weight loss and insulin-sensitizing factor. Growing evidence also supports a role for GDF15 as a physiological, exercise-induced stress signal. Here, we tested whether GDF15 is required for the insulin-sensitizing effects of exercise in mice and humans. At baseline, both under a standard nutritional state and high-fat feeding, GDF15 knockout (KO) mice display normal glucose tolerance, systemic insulin sensitivity, maximal speed, and endurance running capacity when compared to wild-type littermates independent of sex. When submitted to a 4-week exercise training program, both lean and obese wild-type and GDF15 KO mice similarly improve their endurance running capacity, glucose tolerance, systemic insulin sensitivity, and peripheral glucose uptake. Insulin-sensitizing effects of exercise training were also unrelated to changes in plasma GDF15 in humans. In summary, we here show that GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124724009069; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2024.114577 |
| Access URL: |
https://doaj.org/article/7d1e0c2e4c374023bf939f007ac20e55 |
| Accession Number: |
edsdoj.7d1e0c2e4c374023bf939f007ac20e55 |
| Database: |
Directory of Open Access Journals |
