Bibliographic Details
| Title: |
Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP |
| Authors: |
María García-García, Sara Sánchez-Perales, Patricia Jarabo, Enrique Calvo, Trevor Huyton, Liran Fu, Sheung Chun Ng, Laura Sotodosos-Alonso, Jesús Vázquez, Sergio Casas-Tintó, Dirk Görlich, Asier Echarri, Miguel A. Del Pozo |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP then controls Importin-7 response to mechanical cues and restricts Importin-7 binding to other cargoes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-28693-y |
| Access URL: |
https://doaj.org/article/7cb59e3af2ed46b8b24506a9c27680be |
| Accession Number: |
edsdoj.7cb59e3af2ed46b8b24506a9c27680be |
| Database: |
Directory of Open Access Journals |
