Academic Journal
Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin
| Title: | Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin |
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| Authors: | Yue Zhou, Hui Xu, Ka-Wing Cheng, Feng Chen, Qian Zhou, Mingfu Wang |
| Source: | Food Science and Human Wellness, Vol 13, Iss 5, Pp 2584-2594 (2024) |
| Publisher Information: | Tsinghua University Press, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Nutrition. Foods and food supply |
| Subject Terms: | glycidol, endothelial cells, 6-c-(e-2-fluorostyryl)naringenin, oxidative stress, endothelial-to-mesenchymal transition, Nutrition. Foods and food supply, TX341-641 |
| More Details: | Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related foodstuffs. Vascular endothelial cells may be potential targets of the deleterious effects associated with glycidol exposure. In human umbilical vein endothelial cells (HUVECs), we found that glycidol treatment promoted endothelialto-mesenchymal transition (EndMT) at a lower concentration (0.5 mmol/L), while induced apoptosis and inflammation at a higher concentration (1 mmol/L). These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species (ROS). In addition, the protective potential of 6-C-(E-2-fluorostyryl)naringenin (6-CEFN) against glycidol was evaluated and compared with naringenin. HUVECs pre-treated with 6-CEFN, but not naringenin, displayed resistance to endothelial dysfunction caused by glycidol. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2097-0765 2213-4530 |
| Relation: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250207; https://doaj.org/toc/2097-0765; https://doaj.org/toc/2213-4530 |
| DOI: | 10.26599/FSHW.2022.9250207 |
| Access URL: | https://doaj.org/article/7ca0c2c412f3479eb3a6084aeb557eaa |
| Accession Number: | edsdoj.7ca0c2c412f3479eb3a6084aeb557eaa |
| Database: | Directory of Open Access Journals |
| ISSN: | 20970765 22134530 |
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| DOI: | 10.26599/FSHW.2022.9250207 |
| Published in: | Food Science and Human Wellness |
| Language: | English |