Population Pharmacokinetics of Vancomycin in Thai Patients
| Title: | Population Pharmacokinetics of Vancomycin in Thai Patients |
|---|---|
| Authors: | Tunggul Adi Purwonugroho, Suvatna Chulavatnatol, Yupaporn Preechagoon, Busba Chindavijak, Kumthorn Malathum, Pakwan Bunuparadah |
| Source: | The Scientific World Journal, Vol 2012 (2012) |
| Publisher Information: | Wiley, 2012. |
| Publication Year: | 2012 |
| Collection: | LCC:Technology LCC:Medicine LCC:Science |
| Subject Terms: | Technology, Medicine, Science |
| More Details: | Population pharmacokinetics of vancomycin in Thai adult patients was determined by non-linear mixed-effects approach using 319 vancomycin serum concentrations from 212 patients. The data were best fitted by a two-compartment model and it was used to examine the effect of patient characteristics on the vancomycin pharmacokinetics. In the final model, there was a linear relationship between vancomycin clearance, CL (L/h), and creatinine clearance calculated by Cockcroft-Gault equation, CLCr (mL/min): CL=0.044×CLCr. Meanwhile, volume of central compartment, 𝑉1 (L), was linearly related with the age (years old): 𝑉1=0.542× Age. Intercompartment clearance (𝑄) and volume of peripheral compartment (𝑉2) was 6.95 L/h and 44.2 L, respectively. The interindividual variability for CL, 𝑉1, 𝑄, and 𝑉2 was 35.78, 20.93, 39.50, and 57.27%, respectively. Whereas, the intraindividual variability was 4.51 mg/L. Final model then was applied to predict serum vancomycin concentrations on validation group. Predictive performance revealed a bias of −1.43 mg/L (95% CI: −5.82–2.99) and a precision of 12.2 mg/L (95% CI: −1.60–26.16). In conclusion, population pharmacokinetic of vancomycin in Thai adult patients was developed. The model could be used to create vancomycin dosage regimen in the type of patient similar with the present study. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1537-744X |
| Relation: | https://doaj.org/toc/1537-744X |
| DOI: | 10.1100/2012/762649 |
| Access URL: | https://doaj.org/article/d7c5ed26b34c4bd3bc43c9a525b18417 |
| Accession Number: | edsdoj.7c5ed26b34c4bd3bc43c9a525b18417 |
| Database: | Directory of Open Access Journals |
| ISSN: | 1537744X |
|---|---|
| DOI: | 10.1100/2012/762649 |
| Published in: | The Scientific World Journal |
| Language: | English |