Meropenem/Vaborbactam: β-Lactam/β-Lactamase Inhibitor Combination, the Future in Eradicating Multidrug Resistance

Bibliographic Details
Title:	Meropenem/Vaborbactam: β-Lactam/β-Lactamase Inhibitor Combination, the Future in Eradicating Multidrug Resistance
Authors:	Anna Duda-Madej, Szymon Viscardi, Ewa Topola
Source:	Antibiotics, Vol 12, Iss 11, p 1612 (2023)
Publisher Information:	MDPI AG, 2023.
Publication Year:	2023
Collection:	LCC:Therapeutics. Pharmacology
Subject Terms:	β-lactam/β-lactamase inhibitor, carbapenem-resistant Enterobacterales (CRE), Klebsiella pneumoniae carbapenemase (KPC), meropenem, multidrug resistance, vaborbactam, Therapeutics. Pharmacology, RM1-950
More Details:	Due to the fact that there is a steadily increasing trend in the area of antimicrobial resistance in microorganisms, there is a need to look for new treatment alternatives. One of them is the search for new β-lactamase inhibitors and combining them with β-lactam antibiotics, with the aim of increasing the low-dose efficacy, as well as lowering the resistance potential of bacterial strains. This review presents the positive effect of meropenem in combination with a vaborbactam (MER-VAB). This latest antibiotic-inhibitor combination has found particular use in the treatment of infections with the etiology of carbapenem-resistant Enterobacterales (CRE), Gram-negative bacteria, with a high degree of resistance to available antimicrobial drugs.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2079-6382 09095772
Relation:	https://www.mdpi.com/2079-6382/12/11/1612; https://doaj.org/toc/2079-6382
DOI:	10.3390/antibiotics12111612
Access URL:	https://doaj.org/article/7c42ce171e4149f090957726250f890f
Accession Number:	edsdoj.7c42ce171e4149f090957726250f890f
Database:	Directory of Open Access Journals

More Details
ISSN:	20796382 09095772
DOI:	10.3390/antibiotics12111612
Published in:	Antibiotics
Language:	English