Bibliographic Details
| Title: |
Detection of lymphoma biomarker ferritin using functionalized carbon nanotube platform |
| Authors: |
Shuang Qu, Chen Wang, Xiaoling Guo, Zhihai Zheng, Biyun Chen, Sicong Jiang |
| Source: |
Alexandria Engineering Journal, Vol 104, Iss , Pp 621-626 (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Engineering (General). Civil engineering (General) |
| Subject Terms: |
Electrochemical immunosensor, Functionalized MWCNTs, Ferritin, Lymphoma biomarker, Point-of-care testing, Engineering (General). Civil engineering (General), TA1-2040 |
| More Details: |
For the detection of ferritin, this work engineered an electrochemical immunosensor by functionalizing multi-walled carbon nanotubes (MWCNTs) and integrating them into a screen-printed carbon electrode (SPCE) platform. Under optimal conditions (pH 7.4, antibody concentration 10 μg/mL, incubation time 30 min), the developed immunosensor exhibited a linear relationship between the electrochemical signal and ferritin concentrations spanning 1–500 ng/mL. Notably, it demonstrated an impressive ability to detect ferritin at exceptionally low levels, with a limit of detection reaching 0.3 ng/mL. The immunosensor demonstrated high selectivity, good reproducibility (RSD = 3.2 %, n = 5), and stability (87.3 % of initial response after 14 days at 4°C). The immunosensor was used to sensing ferritin in serum and good agreement with the commercial ELISA method (relative error < 5 %). The proposed sensor shows promise as a analytical approach for early diagnosis of lymphoma and point-of-care testing. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1110-0168 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1110016824008767; https://doaj.org/toc/1110-0168 |
| DOI: |
10.1016/j.aej.2024.07.133 |
| Access URL: |
https://doaj.org/article/7c2a93653be04ad6beb11d61a6cc8730 |
| Accession Number: |
edsdoj.7c2a93653be04ad6beb11d61a6cc8730 |
| Database: |
Directory of Open Access Journals |
