Bibliographic Details
| Title: |
The association between serum uric acid levels and 10-year cardiovascular disease incidence: results from the ATTICA prospective study |
| Authors: |
Niki Katsiki, Matina Kouvari, Demosthenes B Panagiotakos, Claudio Borghi, Christina Chrysohoou, Dimitri P Mikhailidis, Christos Pitsavos |
| Source: |
Reviews in Cardiovascular Medicine, Vol 22, Iss 3, Pp 991-1001 (2021) |
| Publisher Information: |
IMR Press, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
serum uric acid, cardiovascular disease, attica study, gender, metabolic health status, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Limited data suggests possible gender-specific association between serum uric acid (SUA) and cardiovascular disease (CVD) incidence. The aim of the present analysis was to evaluate the association between SUA levels and 10-year CVD incidence (2002–2012) in the ATTICA study participants. Overall, 1687 apparently healthy volunteers, with SUA measurements, residing in the greater metropolitan Athens area (Greece), were included. Multivariable Cox-regression models were used to estimate the hazard ratios for SUA in relation to 10-year CVD incidence. Receiver operating curve analysis was conducted to detect optimal SUA cut-off values. Participants in the 2nd and 3rd SUA tertile had 29 and 73% higher 10-year CVD incidence compared with those in the 1st tertile (p < 0.001). In gender-specific analysis, only in women SUA was independently associated with CVD incidence; women in the 3rd SUA tertile had 79% greater 10-year CVD event risk compared to their 1st tertile counterparts. Obese in the 3rd SUA tertile had 2-times higher CVD incidence compared to those in the 1st tertile. Similar findings were observed in metabolically healthy (vs. unhealthy) and metabolically healthy obese. SUA thresholds best predicting 10-year CVD incidence was 5.05 and 4.15 mg/dL (0.30 and 0.25 mmol/L) in men and women, respectively. In conclusion, increased SUA levels were independently related to 10-year CVD event rate in women, obese and metabolically healthy individuals. SUA could predict 10-year CVD incidence even at low levels. Further studies are warranted to identify SUA cut-off values that may improve the detection of individuals at higher CVD risk in clinical practice. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2153-8174 |
| Relation: |
https://rcm.imrpress.com/fileup/2153-8174/PDF/1632453102910-165165311.pdf; https://doaj.org/toc/2153-8174 |
| DOI: |
10.31083/j.rcm2203108 |
| Access URL: |
https://doaj.org/article/d7bf2371aa534ac9bdaaa265a72e1a36 |
| Accession Number: |
edsdoj.7bf2371aa534ac9bdaaa265a72e1a36 |
| Database: |
Directory of Open Access Journals |
