Bibliographic Details
| Title: |
Investigating the Spectrum of Biological Activity of Ring-Substituted Salicylanilides and Carbamoylphenylcarbamates |
| Authors: |
Josef Jampilek, Des R. Richardson, Jozef Csollei, Aidan Coffey, Zuzana Mandelova, Danuta S. Kalinowski, Marcela Vejsova, Frantisek Sersen, Katarina Kralova, Jiahui Guo, Matus Pesko, Jan Otevrel, Zaklina Kovacevic |
| Source: |
Molecules, Vol 15, Iss 11, Pp 8122-8142 (2010) |
| Publisher Information: |
MDPI AG, 2010. |
| Publication Year: |
2010 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
salicylanilides, lipophilicity, EPR study, photosynthetic electron transport inhibition, spinach chloroplasts, in vitro anti-fungal activity, in vitro anti-bacterial activity, in vitro anti-mycobacterial activity, anti-proliferative activity, Organic chemistry, QD241-441 |
| More Details: |
In this study, a series of twelve ring-substituted salicylanilides and carbamoylphenylcarbamates were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Moreover, their site of action in the photosynthetic apparatus was determined. Primary in vitro screening of the synthesized compounds was also performed against mycobacterial, bacterial and fungal strains. Several compounds showed biological activity comparable with or higher than the standards 3-(3,4-dichlorophenyl)-1,1-dimethylurea, isoniazid, penicillin G, ciprofloxacin or fluconazole. The most active compounds showed minimal anti-proliferative activity against human cells in culture, indicating they would have low cytotoxicity. For all compounds, the relationships between lipophilicity and the chemical structure are discussed. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
http://www.mdpi.com/1420-3049/15/11/8122/; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules15118122 |
| Access URL: |
https://doaj.org/article/7bdad05729f247759a5eb04643106576 |
| Accession Number: |
edsdoj.7bdad05729f247759a5eb04643106576 |
| Database: |
Directory of Open Access Journals |
