Bibliographic Details
| Title: |
Anaphylaxis to Pfizer/BioNTech mRNA COVID-19 Vaccine in a Patient With Clinically Confirmed PEG Allergy |
| Authors: |
Morgan D. McSweeney, Manoj Mohan, Scott P. Commins, Samuel K. Lai |
| Source: |
Frontiers in Allergy, Vol 2 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
vaccine allergy, vaccine adverse event, anaphylaxis, polyethylene glycol, anti-PEG antibodies, liposome, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Although allergic responses to the mRNA COVID-19 vaccines are rare, recent reports have suggested that a small number of individuals with allergy to polyethylene glycol (PEG), a component of the mRNA lipid nanoshell, may be at increased risk of anaphylaxis following vaccination. In this report, we describe a case of a patient who received an mRNA COVID-19 vaccine, experienced anaphylaxis, and was subsequently confirmed to have anti-PEG allergy by skin prick testing. The patient had previously noticed urticaria after handling PEG powder for their occupation and had a history of severe allergic response to multiple other allergens. Importantly, as many as 70% of people possess detectable levels of anti-PEG antibodies, indicating that the detection of such antibodies does not imply high risk for an anaphylactic response to vaccination. However, in people with pre-existing anti-PEG antibodies, the administration of PEGylated liposomes may induce higher levels of antibodies, which may cause accelerated clearance of other PEGylated therapeutics a patient may be receiving. It is important to improve awareness of PEG allergy among patients and clinicians. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-6101 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/falgy.2021.715844/full; https://doaj.org/toc/2673-6101 |
| DOI: |
10.3389/falgy.2021.715844 |
| Access URL: |
https://doaj.org/article/7bcc3d3447d44db7b6e94384610c9ab5 |
| Accession Number: |
edsdoj.7bcc3d3447d44db7b6e94384610c9ab5 |
| Database: |
Directory of Open Access Journals |
