Possible involvement of Interleukin‐17A in the deterioration of prepulse inhibition on acoustic startle response in mice

Bibliographic Details
Title:	Possible involvement of Interleukin‐17A in the deterioration of prepulse inhibition on acoustic startle response in mice
Authors:	Chisato Wakabayashi, Hiroshi Kunugi
Source:	Neuropsychopharmacology Reports, Vol 43, Iss 3, Pp 365-372 (2023)
Publisher Information:	Wiley, 2023.
Publication Year:	2023
Collection:	LCC:Therapeutics. Pharmacology LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Subject Terms:	GSK3, IL‐17A, mouse, prepulse inhibition, sensorimotor gating, striatum, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
More Details:	Abstract Aim Proinflammatory cytokines such as interleukin‐6 (IL‐6) and IL‐17A have been implicated in the pathophysiology of schizophrenia which often shows sensorimotor gating abnormalities. This study aimed to examine whether a proinflammatory cytokine, IL‐17A, induces impairment in sensorimotor gating in mice. We also examined whether IL‐17A administration affects GSK3α/β protein level or phosphorylation in the striatum. Methods Recombinant mouse IL‐17A (low‐dose: 0.5 ng/mL and high‐dose: 50 ng/mL with 10 μL/g mouse body weight, respectively) or vehicle was intraperitoneally administered into C57BL/6 male mice 10 times in 3 weeks (sub‐chronic administration). Prepulse inhibition test using acoustic startle stimulus was conducted 4 weeks after the final IL‐17A administration. We evaluated the effect of IL‐17A administration on protein level or phosphorylation of GSK3α/β in the striatum by using Western blot analysis. Results Administration of IL‐17A induced significant PPI deterioration. Low‐dose of IL‐17A administration significantly decreased both GSK3α (Ser21) and GSK3β (Ser9) phosphorylation in mouse striatum. There was no significant alteration of GSK3α/β protein levels except for GSK3α in low‐dose IL‐17A administration group. Conclusion We demonstrated for the first time that sub‐chronic IL‐17A administration induced PPI disruption and that IL‐17A administration resulted in decreased phosphorylation of GSKα/β at the striatum. These results suggest that IL‐17A could be a target molecule in the prevention and treatment of sensorimotor gating abnormalities observed in schizophrenia.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2574-173X
Relation:	https://doaj.org/toc/2574-173X
DOI:	10.1002/npr2.12351
Access URL:	https://doaj.org/article/7bcaffb3fd4c40dcafd0ad0884cf9799
Accession Number:	edsdoj.7bcaffb3fd4c40dcafd0ad0884cf9799
Database:	Directory of Open Access Journals

More Details
ISSN:	2574173X
DOI:	10.1002/npr2.12351
Published in:	Neuropsychopharmacology Reports
Language:	English