Academic Journal
Fathers’ preconception smoking and offspring DNA methylation
| Title: | Fathers’ preconception smoking and offspring DNA methylation |
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| Authors: | Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes, John W. Holloway |
| Source: | Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023) |
| Publisher Information: | BMC, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Genetics |
| Subject Terms: | Preconception, Paternal effects, Tobacco smoke, Epigenetic, Epigenome-wide association study, DNA methylation, Medicine, Genetics, QH426-470 |
| More Details: | Abstract Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father’s preconception smoking. Methods We conducted epigenome-wide association studies (EWAS) in the RHINESSA cohort (7–50 years) on father’s any preconception smoking (n = 875 offspring) and father’s pubertal onset smoking |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1868-7083 |
| Relation: | https://doaj.org/toc/1868-7083 |
| DOI: | 10.1186/s13148-023-01540-7 |
| Access URL: | https://doaj.org/article/7bb1818eff03482287d1956a47ca6829 |
| Accession Number: | edsdoj.7bb1818eff03482287d1956a47ca6829 |
| Database: | Directory of Open Access Journals |
| ISSN: | 18687083 |
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| DOI: | 10.1186/s13148-023-01540-7 |
| Published in: | Clinical Epigenetics |
| Language: | English |