Bibliographic Details
| Title: |
Characteristics of changes in plasma proteome profiling after sleeve gastrectomy |
| Authors: |
Yuying Zhang, Chenye Shi, Haifu Wu, Hongmei Yan, Mingfeng Xia, Heng Jiao, Di Zhou, Wei Wu, Ming Zhong, Wenhui Lou, Xin Gao, Hua Bian, Xinxia Chang |
| Source: |
Frontiers in Endocrinology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
bariatric surgery, proteomics, morbid obesity, metabolism, weight loss, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
Bariatric surgery (BS), recognized as the most effective intervention for morbid obesity and associated metabolic comorbidities, encompasses both weight loss-dependent and weight loss-independent mechanisms to exert its metabolic benefits. In this study, we employed plasma proteomics technology, a recently developed mass spectrometric approach, to quantitatively assess 632 circulating proteins in a longitudinal cohort of 9 individuals who underwent sleeve gastrectomy (SG). Through time series clustering and Gene Ontology (GO) enrichment analysis, we observed that complement activation, proteolysis, and negative regulation of triglyceride catabolic process were the primary biological processes enriched in down-regulated proteins. Conversely, up-regulated differentially expressed proteins (DEPs) were significantly associated with negative regulation of peptidase activity, fibrinolysis, keratinocyte migration, and acute-phase response. Notably, we identified seven proteins (ApoD, BCHE, CNDP1, AFM, ITIH3, SERPINF1, FCN3) that demonstrated significant alterations at 1-, 3-, and 6-month intervals post SG, compared to baseline. These proteins play essential roles in metabolism, immune and inflammatory responses, as well as oxidative stress. Consequently, they hold promising potential as therapeutic targets for combating obesity and its associated comorbidities. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2024.1330139/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2024.1330139 |
| Access URL: |
https://doaj.org/article/7b81617651c644b69808a4d02f736d33 |
| Accession Number: |
edsdoj.7b81617651c644b69808a4d02f736d33 |
| Database: |
Directory of Open Access Journals |
