Bibliographic Details
| Title: |
Metagenome-assembled genomes indicate that antimicrobial resistance genes are highly prevalent among urban bacteria and multidrug and glycopeptide resistances are ubiquitous in most taxa |
| Authors: |
Stefanía Magnúsdóttir, Joao Pedro Saraiva, Alexander Bartholomäus, Majid Soheili, Rodolfo Brizola Toscan, Junya Zhang, Ulisses Nunes da Rocha, CLUE-TERRA consortium |
| Source: |
Frontiers in Microbiology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Antimicrobial resistance, urban, prevalence, metagenome-assembled genome, bacteria, virulence factor, Microbiology, QR1-502 |
| More Details: |
IntroductionEvery year, millions of deaths are associated with the increased spread of antimicrobial resistance genes (ARGs) in bacteria. With the increasing urbanization of the global population, the spread of ARGs in urban bacteria has become a more severe threat to human health.MethodsIn this study, we used metagenome-assembled genomes (MAGs) recovered from 1,153 urban metagenomes in multiple urban locations to investigate the fate and occurrence of ARGs in urban bacteria. Additionally, we analyzed the occurrence of these ARGs on plasmids and estimated the virulence of the bacterial species.ResultsOur results showed that multidrug and glycopeptide ARGs are ubiquitous among urban bacteria. Additionally, we analyzed the deterministic effects of phylogeny on the spread of these ARGs and found ARG classes that have a non-random distribution within the phylogeny of our recovered MAGs. However, few ARGs were found on plasmids and most of the recovered MAGs contained few virulence factors.DiscussionOur results suggest that the observed non-random spreads of ARGs are not due to the transfer of plasmids and that most of the bacteria observed in the study are unlikely to be virulent. Additional research is needed to evaluate whether the ubiquitous and widespread ARG classes will become entirely prevalent among urban bacteria and how they spread among phylogenetically distinct species. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-302X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmicb.2023.1037845/full; https://doaj.org/toc/1664-302X |
| DOI: |
10.3389/fmicb.2023.1037845 |
| Access URL: |
https://doaj.org/article/e7b65c411c6a414489cba239eaac29bf |
| Accession Number: |
edsdoj.7b65c411c6a414489cba239eaac29bf |
| Database: |
Directory of Open Access Journals |
