Bibliographic Details
| Title: |
Long-term use of somatostatin analogs for chronic gastrointestinal bleeding in hereditary hemorrhagic telangiectasia |
| Authors: |
Raquel Torres-Iglesias, José María Mora-Luján, Adriana Iriarte, Pau Cerdà, Esther Alba, Miguel Ángel Sánchez-Corral, Ana Berrozpe, Francesc Cruellas, Enric Gamundí, Jesús Ribas, Jose Castellote, Antoni Riera-Mestre |
| Source: |
Frontiers in Medicine, Vol 10 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
hereditary hemorrhagic telangectasia, gastrointestinal bleeding, anemia, somatostatin analogs, rare diseases, Medicine (General), R5-920 |
| More Details: |
BackgroundChronic bleeding due to gastrointestinal (GI) involvement in patients with hemorrhagic hereditary telangiectasia (HHT) can provoke severe anemia with high red blood cells (RBC) transfusion requirements. However, the evidence about how to deal with these patients is scarce. We aimed to assess the long-term efficacy and safety of somatostatin analogs (SA) for anemia management in HHT patients with GI involvement.MethodsThis is a prospective observational study including patients with HHT and GI involvement attended at a referral center. SA were considered for those patients with chronic anemia. Anemia-related variables were compared in patients receiving SA before and during treatment. Patients receiving SA were divided into responders (patients with minimal hemoglobin levels improvement >10 g/L and maintaining hemoglobin levels ≥80 g/L during treatment), and non-responders. Adverse effects during follow-up were collected.ResultsAmong 119 HHT patients with GI involvement, 67 (56.3%) received SA. These patients showed lower minimal hemoglobin levels (73 [60–87] vs. 99 [70.2–122.5], p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1146080/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2023.1146080 |
| Access URL: |
https://doaj.org/article/eaa7b1d405214628a7019fa81935a3f1 |
| Accession Number: |
edsdoj.7b1d405214628a7019fa81935a3f1 |
| Database: |
Directory of Open Access Journals |
