Anemia and survival in childhood acute lymphoblastic leukemia
| Title: | Anemia and survival in childhood acute lymphoblastic leukemia |
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| Authors: | Oliver Teuffel, Martin Stanulla, Gunnar Cario, Wolf D. Ludwig, Silja Rottgers, Beat W. Schafer, Martin Zimmermann, Martin Schrappe, Felix K. Niggli |
| Source: | Haematologica, Vol 93, Iss 11 (2008) |
| Publisher Information: | Ferrata Storti Foundation, 2008. |
| Publication Year: | 2008 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: | Background Several studies have demonstrated that patients with childhood acute lymphoblastic leukemia presenting with mild anemia at diagnosis have an increased risk of poor outcome compared to patients with more severe anemia. However, it has not been reported whether there is any correlation between degree of anemia and leukemia subtype.Design and Methods In a cohort of 1162 patients with childhood acute lymphoblastic leukemia we analyzed whether there was a correlation between degree of anemia and leukemia subtype. We also studied the association between degree of anemia and event-free survival within the subtypes.Results Hemoglobin levels at diagnosis were distributed in a non-random pattern. The degree of anemia was significantly different for three distinct groups of patients compared to the remaining patients (mean hemoglobin; T-cell leukemia: 106 g/L versus 76 g/L (precursor B-cell acute lymphoblastic leukemia); within precursor B-cell ALL: TEL-AML1 positive: 68 g/L versus 79 g/L; BCR-ABL positive: 93 g/L versus 76 g/L; each p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0390-6078 1592-8721 |
| Relation: | https://haematologica.org/article/view/5069; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721 |
| DOI: | 10.3324/haematol.13156 |
| Access URL: | https://doaj.org/article/7b0cfe924ad64d628908d28117d618dc |
| Accession Number: | edsdoj.7b0cfe924ad64d628908d28117d618dc |
| Database: | Directory of Open Access Journals |
| ISSN: | 03906078 15928721 |
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| DOI: | 10.3324/haematol.13156 |
| Published in: | Haematologica |
| Language: | English |