Academic Journal
Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer
| Title: | Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer |
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| Authors: | Feifei Pu, Fengxia Chen, Zhicai Zhang, Deyao Shi, Binlong Zhong, Xiao Lv, Andrew Blake Tucker, Jiaming Fan, Alexander J. Li, Kevin Qin, Daniel Hu, Connie Chen, Hao Wang, Fang He, Na Ni, Linjuan Huang, Qing Liu, William Wagstaff, Hue H. Luu, Rex C. Haydon, Le Shen, Tong-Chuan He, Jianxiang Liu, Zengwu Shao |
| Source: | Genes and Diseases, Vol 9, Iss 2, Pp 347-357 (2022) |
| Publisher Information: | KeAi Communications Co., Ltd., 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine (General) LCC:Genetics |
| Subject Terms: | Cancer, Cancer therapy, Clinical application, Ferroptosis, Lipid peroxidation, Pathogenesis, Medicine (General), R5-920, Genetics, QH426-470 |
| More Details: | The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy. Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells. Anti-tumor drugs were developed to induce apoptosis, but some patient’s show apoptosis escape and chemotherapy resistance. Therefore, other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment. Ferroptosis is a newly discovered iron-dependent, non-apoptotic type of cell death that is highly negatively correlated with cancer development. Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352304220301562; https://doaj.org/toc/2352-3042 |
| DOI: | 10.1016/j.gendis.2020.11.019 |
| Access URL: | https://doaj.org/article/7ada6379f31f407297d60e372884c349 |
| Accession Number: | edsdoj.7ada6379f31f407297d60e372884c349 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523042 |
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| DOI: | 10.1016/j.gendis.2020.11.019 |
| Published in: | Genes and Diseases |
| Language: | English |