Bibliographic Details
| Title: |
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2 |
| Authors: |
Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin |
| Source: |
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
| Publisher Information: |
Nature Portfolio, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/ncomms11316 |
| Access URL: |
https://doaj.org/article/7ab848514085441b822b8a2f77f90739 |
| Accession Number: |
edsdoj.7ab848514085441b822b8a2f77f90739 |
| Database: |
Directory of Open Access Journals |
