| Title: |
The antibacterial and anti-biofilm effects of novel synthetized nitroimidazole compounds against methicillin-resistant Staphylococcus aureus and carbapenem-resistant Escherichia coli and Klebsiella pneumonia in vitro and in silico |
| Authors: |
Elham Zarenezhad, Esmaeil Behmard, Raziyeh Karami, Somayeh Behrouz, Mahrokh Marzi, Abdolmajid Ghasemian, Mohammad Navid Soltani Rad |
| Source: |
BMC Chemistry, Vol 18, Iss 1, Pp 1-21 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Chemistry |
| Subject Terms: |
Antibiotic resistance, Biofilms, Methicillin-resistant Staphylococcus aureus, Carbapenem resistance, Nitroimidazole compounds, Chemistry, QD1-999 |
| More Details: |
Abstract The antibiotic resistance and biofilm formation by bacterial pathogens has led to failure in infections elimination. This study aimed to assess the antibacterial and anti-biofilm properties of novel synthesized nitroimidazole compounds (8a–8o). In this study, nitroimidazole compounds were synthesized via the A3 coupling reaction of sample substrates in the presence of copper-doped silica cuprous sulfate (CDSCS). Fifteen and two carbapenemase producing Escherichia coli and Klebsiella pneumonia (CP-E. coli and CP-K. pneumonia, respectively) and one methicillin-resistant Staphylococcus aureus (MRSA) and one methicillin-susceptible S. aureus (MSSA) plus standard strain of each isolate were included. The antibacterial effects of these compounds demonstrated that the lowest minimum inhibitory and bactericidal concentrations (MIC/MBC, respectively) levels corresponded to compound 8g against S. aureus (1/2 µg/mL) and K. pneumonia (8/32 µg/mL) standard and clinical strains and confirmed by in silico assessment. This was comparable to those of metronidazole being 32–128 µg/mL against K. pneumonia and 32–64 µg/mL against S. aureus. In comparison to metronidazole, against CP-E. coli, compounds 8i and 8m had significantly higher antibacterial effects (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2661-801X |
| Relation: |
https://doaj.org/toc/2661-801X |
| DOI: |
10.1186/s13065-024-01333-w |
| Access URL: |
https://doaj.org/article/ce7a7ecdcad1485d986a237e33b46b3b |
| Accession Number: |
edsdoj.7a7ecdcad1485d986a237e33b46b3b |
| Database: |
Directory of Open Access Journals |
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