Bibliographic Details
| Title: |
Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus |
| Authors: |
Lucrezia Furian, Uwe Heemann, Mats Bengtsson, Oriol Bestard, Isabelle Binet, Georg A. Böhmig, John Boletis, David Briggs, Frans H. J. Claas, Lionel Couzi, Emanuele Cozzi, Marta Crespo, Aiko P. J. De Vries, Fritz Diekmann, Magdalena Durlik, Denis Glotz, Ilkka Helantera, Annette Jackson, Stanley C. Jordan, Dirk Kuypers, Carmen Lefaucheur, Christophe Legendre, Tomas Lorant, Umberto Maggiore, Nizam Mamode, Smaragdi Marinaki, Annick Massart, Thomas Müller, Rainer Oberbauer, Lutz Renders, Dave Roelen, Jean-Luc Taupin, Ondřej Viklický, Angeliki Vittoraki, Annelies E. de Weerd, Maarten Naesens |
| Source: |
Transplant International, Vol 37 (2025) |
| Publisher Information: |
Frontiers Media S.A., 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Specialties of internal medicine |
| Subject Terms: |
desensitization, HLA incompatible, HLAi, kidney transplantation, imlifidase, Specialties of internal medicine, RC581-951 |
| More Details: |
Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid and removes total body immunoglobulin G (IgG) to a greater extent than other methods, enables transplantation to occur between HLA-incompatible (HLAi) donor–recipient pairs and allows patients to have greater access to KTx. However, when the project was launched there was limited data and clinical experience with desensitization in general and with imlifidase specifically. Hence, this Delphi methodology was used to reach a consensus from a multi-disciplinary team (MDT) of experts from 15 countries on the management of HS patients undergoing imlifidase HLAi from a deceased donor (DD) KTx. This Delphi consensus provides clinical practice guidance on the use of imlifidase in the end-to-end management of HS patients undergoing an HLAi DD KTx and supports centers in the development of guidelines for the utilization and integration of imlifidase into clinical practice. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1432-2277 |
| Relation: |
https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13886/full; https://doaj.org/toc/1432-2277 |
| DOI: |
10.3389/ti.2024.13886 |
| Access URL: |
https://doaj.org/article/7a7e636d154148be84ffb8f31a6b03fc |
| Accession Number: |
edsdoj.7a7e636d154148be84ffb8f31a6b03fc |
| Database: |
Directory of Open Access Journals |
