| Title: |
Brain tissue oxygen monitoring in traumatic brain injury: part I—To what extent does PbtO2 reflect global cerebral physiology? |
| Authors: |
Teodor Svedung Wettervik, Erta Beqiri, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson, Peter Smielewski |
| Source: |
Critical Care, Vol 27, Iss 1, Pp 1-11 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: |
Cerebral perfusion pressure, Intracranial pressure, Pressure reactivity index, Traumatic brain injury, Brain tissue oxygenation, Multimodality monitoring, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: |
Abstract Background The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviation from the PRx-based optimal CPP value (∆CPPopt; actual CPP-CPPopt) in relation to brain tissue oxygenation (pbtO2) in traumatic brain injury (TBI). Methods A total of 425 TBI patients with ICP- and pbtO2 monitoring for at least 12 h, who had been treated at the neurocritical care unit, Addenbrooke’s Hospital, Cambridge, UK, between 2002 and 2022 were included. Generalized additive models (GAMs) and linear mixed effect models were used to explore the association of ICP, PRx, CPP, and CPPopt in relation to pbtO2. PbtO2 20 mmHg, PRx > 0.30, CPP 20 mmHg, PRx > 0.30, CPP |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1364-8535 |
| Relation: |
https://doaj.org/toc/1364-8535 |
| DOI: |
10.1186/s13054-023-04627-y |
| Access URL: |
https://doaj.org/article/7a4bbf609f584605903737ba8e6de149 |
| Accession Number: |
edsdoj.7a4bbf609f584605903737ba8e6de149 |
| Database: |
Directory of Open Access Journals |
