Academic Journal
Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis
| Title: | Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis |
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| Authors: | Pei Xie, Liying Zhang, Hui Shen, Hang Wu, Jiulong Zhao, Shige Wang, Lianghao Hu |
| Source: | Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-18 (2022) |
| Publisher Information: | BMC, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | MoSe2-polyvinylpyrrolidone, Biodegradable nanoparticles, Reactive oxygen species, Acute pancreatitis, Nanozyme, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract Exogenous antioxidant materials mimicking endogenous antioxidant systems are commonly used for the treatment of oxidative stress-induced injuries. Thus, artificial enzymes have emerged as promising candidates for balancing and treating the dysregulation of redox homeostasis in vivo. Herein, a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs) is reported. The synthesized NPs were biodegradable due to their exposure to oxygen and exhibited high stability. Moreover, they effectively mimicked various naturally occurring enzymes (including catalase, superoxide dismutase, peroxidase, and glutathione peroxidase) and scavenged free radicals, such as 3-ethylbenzothiazoline-6-sulfonic acid, ·OH, ·O2−, and 1,1-diphenyl-2-picrylhydrazyl radical. Further apoptosis detection studies revealed that MoSe2-PVP NPs significantly increased the cell survival probability in H2O2 in a concentration-dependent manner. The cytoprotective effect of MoSe2-PVP NPs was explored for an animal model of acute pancreatitis, which confirmed its remarkable therapeutic efficacy. Owing to the biodegradable and biocompatible nature of MoSe2-PVP NPs, the findings of this work can stimulate the development of other artificial nanoenzymes for antioxidant therapies. Graphical Abstract |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-022-01288-x |
| Access URL: | https://doaj.org/article/7a3f29ad154a4bd5afb9c717252c1679 |
| Accession Number: | edsdoj.7a3f29ad154a4bd5afb9c717252c1679 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14773155 |
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| DOI: | 10.1186/s12951-022-01288-x |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |