Academic Journal
Targeting membrane contact sites to mediate lipid dynamics: innovative cancer therapies
| Title: | Targeting membrane contact sites to mediate lipid dynamics: innovative cancer therapies |
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| Authors: | Jie Wang, Meifeng Wang, Xueni Zeng, Yanhan Li, Lingzhi Lei, Changan Chen, Xi Lin, Peiyuan Fang, Yuxuan Guo, Xianjie Jiang, Yian Wang, Lihong Chen, Jun Long |
| Source: | Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-26 (2025) |
| Publisher Information: | BMC, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Cytology |
| Subject Terms: | Membrane contact sites, Lipid metabolism, Organelle interactions, Cancer metabolism, Anticancer therapy, Medicine, Cytology, QH573-671 |
| More Details: | Abstract Membrane contact sites (MCS) are specialized regions where organelles are closely interconnected through membrane structures, facilitating the transfer and exchange of ions, lipids, and other molecules. This proximity enables a synergistic regulation of cellular homeostasis and functions. The formation and maintenance of these contact sites are governed by specific proteins that bring organelle membranes into close apposition, thereby enabling functional crosstalk between cellular compartments. In eukaryotic cells, lipids are primarily synthesized and metabolized within distinct organelles and must be transported through MCS to ensure proper cellular function. Consequently, MCS act as pivotal platforms for lipid synthesis and trafficking, particularly in cancer cells and immune cells within the tumor microenvironment, where dynamic alterations are critical for maintaining lipid homeostasis. This article provides a comprehensive analysis of how these cells exploit membrane contact sites to modulate lipid synthesis, metabolism, and transport, with a specific focus on how MCS-mediated lipid dynamics influence tumor progression. We also examine the differences in MCS and associated molecules across various cancer types, exploring novel therapeutic strategies targeting MCS-related lipid metabolism for the development of anticancer drugs, while also addressing the challenges involved. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-025-02089-z |
| Access URL: | https://doaj.org/article/ac7a17434dbc4abfa2c6b3a51b26a545 |
| Accession Number: | edsdoj.7a17434dbc4abfa2c6b3a51b26a545 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1478811X |
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| DOI: | 10.1186/s12964-025-02089-z |
| Published in: | Cell Communication and Signaling |
| Language: | English |