Bibliographic Details
| Title: |
Clinical and immunological characteristics of high-risk double-hit multiple myeloma |
| Authors: |
Yufeng Shang, Guopeng Chen, Li Liu, Ruiyang Pan, Xinqi Li, Hui Shen, Yuxin Tan, Linlu Ma, Xiqin Tong, Weida Wang, Xiaoqin Chen, Zhongjun Xia, Xiaoyan Liu, Fuling Zhou |
| Source: |
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Double-hit multiple myeloma, Bone marrow immune microenvironment, Tregs, TGF-β1, PD-1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract At present, the characteristics of double-hit multiple myeloma (DHMM) are unknown. We retrospectively analyzed the clinical data from 433 new diagnosed MM patients and found that DHMM have a higher β2-MG level and percentage of bone marrow plasma cell. Cox regression analysis showed that the prognosis of DHMM was not limited by clinical indicators. The abnormal proliferation of bone marrow in DHMM is obvious, and the proportion of poorly differentiated plasma cell is high. By collecting specimens from our center and performing flow cytometry to analyze the immunophenotypic and functional characteristics of lymphocyte subpopulations, we found that DHMM had a higher ratio of Tregs cells, and the proportion of iTregs cells was also significantly higher than non-DHMM (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2407 |
| Relation: |
https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-024-13124-6 |
| Access URL: |
https://doaj.org/article/79c965582c8b4c9da66af54724a3133a |
| Accession Number: |
edsdoj.79c965582c8b4c9da66af54724a3133a |
| Database: |
Directory of Open Access Journals |
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