Bibliographic Details
| Title: |
The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study |
| Authors: |
Silin Liang, Mai Shi, Yunpeng Bai, Yujun Deng, Miaoxian Fang, Jiaxin Li, Yijin Wu, Wenying Peng, Yating Hou, Heng Fang, Huidan Zhang, Chunbo Chen |
| Source: |
BMC Nephrology, Vol 21, Iss 1, Pp 1-10 (2020) |
| Publisher Information: |
BMC, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: |
Acute kidney injury, Cystatin C, Intensive care unit, Renal biomarker, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: |
Abstract Background Glucocorticoids may impact the accuracy of serum cystatin C (sCysC) in reflecting renal function. We aimed to assess the effect of glucocorticoids on the performance of sCysC in detecting acute kidney injury (AKI) in critically ill patients. Methods A prospective observational cohort study was performed in a general intensive care unit (ICU). Using propensity score matching, we successfully matched 240 glucocorticoid users with 960 non-users among 2716 patients. Serum creatinine (SCr) and sCysC were measured for all patients at ICU admission. Patients were divided into four groups based on cumulative doses of glucocorticoids within 5 days before ICU admission (Group I: non-users; Group II: 0 mg 150 mg). We compared the performance of sCysC for diagnosing and predicting AKI in different groups using the area under the receiver operator characteristic curve (AUC). Results A total of 240 patients received glucocorticoid medication within 5 days before ICU admission. Before and after matching, the differences of sCysC levels between glucocorticoid users and non-users were both significant (P 0.05). Simultaneously, we did not find significant differences in the AUC between any two groups in the matched cohort (P > 0.05). Conclusions Glucocorticoids did not impact the performance of sCysC in identifying AKI in critically ill patients. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2369 |
| Relation: |
https://doaj.org/toc/1471-2369 |
| DOI: |
10.1186/s12882-020-02165-1 |
| Access URL: |
https://doaj.org/article/a79889da99e54f26900db06d434714c5 |
| Accession Number: |
edsdoj.79889da99e54f26900db06d434714c5 |
| Database: |
Directory of Open Access Journals |
