Bibliographic Details
| Title: |
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein |
| Authors: |
Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 38 is dependent on the amino-acid introduced, suggesting that specific interactions control α -Syn aggregation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-32687-1 |
| Access URL: |
https://doaj.org/article/795dea3b15b941688aa5f281361c1332 |
| Accession Number: |
edsdoj.795dea3b15b941688aa5f281361c1332 |
| Database: |
Directory of Open Access Journals |
