Bibliographic Details
| Title: |
Follow-up study of neuropsychological scores of infant patients with cobalamin C defects and influencing factors of cerebral magnetic resonance imaging characteristics |
| Authors: |
Tao Chen, Chaofan Sui, Suna Lin, Bin Guo, Yuanyuan Wang, Linfeng Yang |
| Source: |
Frontiers in Neuroscience, Vol 16 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
cblC defect, inborn error of metabolism, magnetic resonance imaging, neuropsychological test, follow-up study, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
PurposeThe purpose of this study was to investigate whether baseline cerebral magnetic resonance imaging (MRI) characteristics could predict therapeutic responsiveness in patients with cobalamin C (cblC) defects.Materials and methodsThe cerebral MRI results of 40 patients with cblC defects were evaluated by a neuroradiologist. Neuropsychological scores and imaging data were collected. Neuropsychological tests were performed before and after standardized treatment.ResultsThirty-eight patients initially underwent neuropsychological testing [developmental quotient (DQ)]. CblC defects with cerebellar atrophy, corpus callosum thinning and ventricular dilation had significantly lower DQs than those without (P < 0.05). Through a multivariate linear stepwise regression equation after univariate analysis, ventricular dilation was the most valuable predictor of lower DQs. Thirty-six patients (94.7%) underwent follow-up neuropsychological testing. The pre- and post-treatment DQ values were not significantly different (Z = −1.611, P = 0.107). The post-treatment DQ classification (normal, moderately low, or extremely low) showed nearly no change compared to the pretreatment DQ classification (k = 0.790, P < 0.001).ConclusionVentricular dilation, cerebral atrophy and corpus callosum thinning are the main MRI abnormalities of cblC defects, and these manifestations are significantly correlated with delayed development in children. MRI findings can be considered an important tool for determining the severity of cblC defects. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1662-453X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnins.2022.1093850/full; https://doaj.org/toc/1662-453X |
| DOI: |
10.3389/fnins.2022.1093850 |
| Access URL: |
https://doaj.org/article/c7941d398ca34e6fa16478420707cad4 |
| Accession Number: |
edsdoj.7941d398ca34e6fa16478420707cad4 |
| Database: |
Directory of Open Access Journals |
