Bibliographic Details
| Title: |
Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research |
| Authors: |
Zeinab Wehbe, Foued Ghanjati, Christian Flotho |
| Source: |
Cells, Vol 10, Iss 9, p 2335 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Cytology |
| Subject Terms: |
JMML, leukemia, reprogramming, IPSC, differentiation, hematopoietic cells, Cytology, QH573-671 |
| More Details: |
Juvenile myelomonocytic leukemia (JMML) is a malignant myeloproliferative disorder arising in infants and young children. The origin of this neoplasm is attributed to an early deregulation of the Ras signaling pathway in multipotent hematopoietic stem/progenitor cells. Since JMML is notoriously refractory to conventional cytostatic therapy, allogeneic hematopoietic stem cell transplantation remains the mainstay of curative therapy for most cases. However, alternative therapeutic approaches with small epigenetic molecules have recently entered the stage and show surprising efficacy at least in specific subsets of patients. Hence, the establishment of preclinical models to test novel agents is a priority. Induced pluripotent stem cells (IPSCs) offer an opportunity to imitate JMML ex vivo, after attempts to generate immortalized cell lines from primary JMML material have largely failed in the past. Several research groups have previously generated patient-derived JMML IPSCs and successfully differentiated these into myeloid cells with extensive phenotypic similarities to primary JMML cells. With infinite self-renewal and the capability to differentiate into multiple cell types, JMML IPSCs are a promising resource to advance the development of treatment modalities targeting specific vulnerabilities. This review discusses current reprogramming techniques for JMML stem/progenitor cells, related clinical applications, and the challenges involved. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/10/9/2335; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells10092335 |
| Access URL: |
https://doaj.org/article/78e84339bd124fec93864011d3c29a57 |
| Accession Number: |
edsdoj.78e84339bd124fec93864011d3c29a57 |
| Database: |
Directory of Open Access Journals |
