Bibliographic Details
| Title: |
Triterpenoids from the Leaves of Diospyros digyna and Their PTP1B Inhibitory Activity |
| Authors: |
Lan Huang, Ziqi Wang, Fangxin Wang, Song Wang, Dezhi Wang, Meihua Gao, Hua Li, Min Song, Xiaoqi Zhang |
| Source: |
Molecules, Vol 29, Iss 7, p 1640 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
Diospyros digyna, Ebenaceae, ursane triterpenoids, PTP1B inhibitory activity, Organic chemistry, QD241-441 |
| More Details: |
Six new 2α-hydroxy ursane triterpenoids, 3α-cis-p-coumaroyloxy-2α,19α-dihydroxy-12-ursen-28-oic acid (1), 3α-trans-p-coumaroyloxy-2α,19α-dihydroxy-12-ursen-28-oic acid (2), 3α-trans-p-coumaroyloxy-2α-hydroxy-12-ursen-28-oic acid (3), 3β-trans-p-coumaroyloxy-2α-hydroxy-12,20(30)-ursadien-28-oic acid (4), 3β-trans-feruloyloxy-2α-hydroxy-12,20(30)-ursadien-28-oic acid (5), and 3α-trans-feruloyloxy-2α-hydroxy-12,20(30)-ursadien-28-oic acid (6), along with eleven known triterpenoids (7–17), were isolated from the leaves of Diospyros digyna. Their chemical structures were elucidated by comprehensive analysis of UV, IR, HRESIMS, and NMR spectra. All the isolated compounds were evaluated for their PTP1B inhibitory activity. 3β-O-trans-feruloyl-2α-hydroxy-urs-12-en-28-oic acid (13) showed the best inhibition activity with an IC50 value of 10.32 ± 1.21 μM. The molecular docking study found that the binding affinity of compound 13 for PTP1B was comparable to that of oleanolic acid (positive control). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/29/7/1640; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules29071640 |
| Access URL: |
https://doaj.org/article/78b6cd95d4f04448a4b56a76eb7796fd |
| Accession Number: |
edsdoj.78b6cd95d4f04448a4b56a76eb7796fd |
| Database: |
Directory of Open Access Journals |
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