Bibliographic Details
| Title: |
Post-operative plasma osteopontin predicts distant metastasis in human colorectal cancer. |
| Authors: |
Lui Ng, Timothy Ming-Hun Wan, Colin Siu-Chi Lam, Ariel Ka-Man Chow, Sunny Kit-Man Wong, Johnny Hon-Wai Man, Hung-Sing Li, Nathan Shiu-Man Cheng, Ryan Chung-Hei Pak, Alvin Ho-Kwan Cheung, Thomas Chung-Cheung Yau, Oswens Siu-Hung Lo, Dominic Chi-Chung Foo, Jensen Tung-Chung Poon, Ronnie Tung-Ping Poon, Roberta Wen-Chi Pang, Wai-Lun Law |
| Source: |
PLoS ONE, Vol 10, Iss 5, p e0126219 (2015) |
| Publisher Information: |
Public Library of Science (PLoS), 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
The overall prognosis of colorectal cancer (CRC) patients is unsatisfactory due to cancer metastasis after operation. This study aims to investigate the clinical significance of plasma osteopontin (OPN) levels as minimally invasive, predictive, and surrogate biomarkers for prognosis of CRC patients.This randomized study design consists of pre-operative and post-operative plasma samples from a total of 79 patients. We determined plasma levels of OPN by ELISA and examined their correlation with the clinicopathological parameters of CRC patients. The effects of endogenous and exogenous OPN on CRC metastasis were investigated by examination of the effect on regulators of epithelial to messenchymal transition and migration assay.Our findings demonstrated for the first time the clinical correlation of plasma OPN with metastasis of CRC patients. High post-operative plasma OPN level (>153.02 ng/ml) associated with development of metastasis after curative resection (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC4427310?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0126219 |
| Access URL: |
https://doaj.org/article/d785229062a24d038bcc332f593a3d78 |
| Accession Number: |
edsdoj.785229062a24d038bcc332f593a3d78 |
| Database: |
Directory of Open Access Journals |
