Bibliographic Details
| Title: |
Seroprevalence study of SARS-CoV-2 antibodies in healthcare workers following the first wave of the COVID-19 pandemic in a tertiary-level hospital in the south of Ireland |
| Authors: |
Corinna Sadlier, John Benson, Deirdre O’Sullivan, Kevin Conlon, John Gallagher, Mary Horgan, Rachel Barry, Joseph A Eustace, Eamonn Faller, Adrianne Wyse, Cormac Everard, Paula Finnegan, Claire Foran, Emer Herlihy, Gerry Kerr, Susan Lapthorne, Aimee McGreal-Bellone, Edmond Morrissey, Grainne O’Sullivan, Declan Spillane, Catherine Dempsey, Mike Prentice, John MacSharry, Liam J Fanning, Stephen O’Riordan |
| Source: |
BMJ Open, Vol 11, Iss 6 (2021) |
| Publisher Information: |
BMJ Publishing Group, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Medicine |
| More Details: |
Objective This study investigated seroprevalence of SARS-CoV-2-specific IgG antibodies, using the Abbott antinucleocapsid IgG chemiluminescent microparticle immunoassay (CMIA) assay, in five prespecified healthcare worker (HCW) subgroups following the first wave of the COVID-19 pandemic.Setting An 800-bed tertiary-level teaching hospital in the south of Ireland.Participants Serum was collected for anti-SARS-CoV-2 nucleocapsid IgG using the Abbott ARCHITECT SARS-CoV-2 IgG CMIA qualitative assay, as per the manufacturer’s specifications.The groups were as follows: (1) HCWs who had real-time PCR (RT-PCR) confirmed COVID-19 infection (>1-month postpositive RT-PCR); (2) HCWs identified as close contacts of persons with COVID-19 infection and who subsequently developed symptoms (virus not detected by RT-PCR on oropharyngeal/nasopharyngeal swab); (3) HCWs identified as close contacts of COVID-19 cases and who remained asymptomatic (not screened by RT-PCR); (4) HCWs not included in the aforementioned groups working in areas determined as high-risk clinical areas; and (5) HCWs not included in the aforementioned groups working in areas determined as low-risk clinical areas.Results Six of 404 (1.49%) HCWs not previously diagnosed with SARS-CoV-2 infection (groups 2–5) were seropositive for SARS-CoV-2 at the time of recruitment into the study.Out of the 99 participants in group 1, 72 had detectable IgG to SARS-CoV-2 on laboratory testing (73%). Antibody positivity correlated with shorter length of time between RT-PCR positivity and antibody testing.Quantification cycle value on RT-PCR was not found to be correlated with antibody positivity.Conclusions Seroprevalence of SARS-CoV-2 antibodies in HCWs who had not previously tested RT-PCR positive for COVID-19 was low compared with similar studies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2044-6055 |
| Relation: |
https://bmjopen.bmj.com/content/11/6/e051415.full; https://doaj.org/toc/2044-6055 |
| DOI: |
10.1136/bmjopen-2021-051415 |
| Access URL: |
https://doaj.org/article/782be8440c8a4d61ba512641eee38300 |
| Accession Number: |
edsdoj.782be8440c8a4d61ba512641eee38300 |
| Database: |
Directory of Open Access Journals |
