Bibliographic Details
| Title: |
Herpesvirus Infection of Endothelial Cells as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| Authors: |
Jean M. Nunes, Douglas B. Kell, Etheresia Pretorius |
| Source: |
Viruses, Vol 16, Iss 4, p 572 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), endothelial cells, herpesvirus, Microbiology, QR1-502 |
| More Details: |
Understanding the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is critical for advancing treatment options. This review explores the novel hypothesis that a herpesvirus infection of endothelial cells (ECs) may underlie ME/CFS symptomatology. We review evidence linking herpesviruses to persistent EC infection and the implications for endothelial dysfunction, encompassing blood flow regulation, coagulation, and cognitive impairment—symptoms consistent with ME/CFS and Long COVID. This paper provides a synthesis of current research on herpesvirus latency and reactivation, detailing the impact on ECs and subsequent systemic complications, including latent modulation and long-term maladaptation. We suggest that the chronicity of ME/CFS symptoms and the multisystemic nature of the disease may be partly attributable to herpesvirus-induced endothelial maladaptation. Our conclusions underscore the necessity for further investigation into the prevalence and load of herpesvirus infection within the ECs of ME/CFS patients. This review offers conceptual advances by proposing an endothelial infection model as a systemic mechanism contributing to ME/CFS, steering future research toward potentially unexplored avenues in understanding and treating this complex syndrome. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/16/4/572; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v16040572 |
| Access URL: |
https://doaj.org/article/7821a992674a4d97b1952a3438ab9557 |
| Accession Number: |
edsdoj.7821a992674a4d97b1952a3438ab9557 |
| Database: |
Directory of Open Access Journals |
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