Bibliographic Details
| Title: |
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer |
| Authors: |
Shih-Chieh Lin, Chung-Yang Kao, Hui-Ju Lee, Chad J. Creighton, Michael M. Ittmann, Shaw-Jenq Tsai, Sophia Y. Tsai, Ming-Jer Tsai |
| Source: |
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| Publisher Information: |
Nature Portfolio, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPFfavouring prostate cancer metastasis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/ncomms11418 |
| Access URL: |
https://doaj.org/article/ea77da78abb94d3e818aa812c14677ef |
| Accession Number: |
edsdoj.77da78abb94d3e818aa812c14677ef |
| Database: |
Directory of Open Access Journals |
